| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3053020 | Epilepsy Research | 2007 | 4 Pages |
Abstract
SummaryTo test the putative serotonin (5-HT)-like effect of zonisamide (ZNS) we employed xanthine-induced epileptiform activity in the hippocampus slice preparation from guinea pigs. In this model Na+- and T-type Ca2+ channel blockers are hardly effective while 5-HT should be inhibitory. Bath application of 5-HT hyperpolarized neurons and abolished theophylline-induced epileptiform activity. In contrast, ZNS failed to alter epileptiform bursting. We conclude that 5-HT augmenting effects of ZNS are missing or are not sufficient to inhibit epileptiform activity in hippocampal slice preparations.
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Authors
Jan Thöne, Martin Wiemann,