| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3053037 | Epilepsy Research | 2008 | 5 Pages |
Abstract
SummaryRasmussen encephalitis (RE) is a rare form of severe unihemispheric epilepsy established to be an autoimmune disease. Here we demonstrate the presence of autoantibodies against Munc18-1 in 20% of patients collective with biopsy-proven RE. Intriguingly, brain biopsy specimens of these patients showed a striking perivascular accentuated infiltration of B-lymphocytes and plasma cells, suggesting a subgroup of RE patients harboring Munc18-1 antibodies and concomitant B- and plasma cell infiltration.
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Authors
Elena Alvarez-Barón, Christian G. Bien, Johannes Schramm, Christian E. Elger, Albert J. Becker, Susanne Schoch,