Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3053423 | Epilepsy Research | 2006 | 5 Pages |
Abstract
Reeler mice are a model of cortical malformation with enhanced seizure susceptibility. Data suggest that the propensity to anesthesia-induced seizures may be enhanced in animal models with developmental anomalies. Consequently, reeler mice were monitored behaviorally before, during and after isoflurane anesthesia. During recovery, 12% of reeler homozygotes had class I/II seizures while the remaining 88% exhibited convulsive seizures entailing opisthotonus and forepaw drumming. Similar behavior was not observed in controls. These data reveal that reeler mice display isoflurane-induced seizures and provide support for the hypothesis that developmental anomalies may predispose the central nervous system to anesthesia-induced seizures.
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Authors
Nicholas N. Kopjas, Ryan T. Jones, Brent Bany, Peter R. Patrylo,