Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3056437 | Experimental Neurology | 2008 | 4 Pages |
Abstract
Replacement of damaged neuronal population by fetal tissue transplantation represents a potential treatment for neurodegenerative diseases. Consistent success has been achieved with fetal striatal transplantation in Huntington's disease animal models and patients. We report the neo-generation of metabolically active tissue with striatum-like imaging features after transplantation of striatal primordia in a patient with Huntington's disease. This study represents the first “in vivo” demonstration that a human striatal anlagen, transplanted into the adult human brain, is able to progress in its development and to generate a new anatomical structure in the host, without evidence of neoplasia or teratoma.
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Authors
Pasquale Gallina, Marco Paganini, Letizia Lombardini, Riccardo Saccardi, Mirca Marini, Maria Teresa De Cristofaro, Pamela Pinzani, Francesca Salvianti, Clara Crescioli, Andrea Di Rita, Sandra Bucciantini, Claudia Mechi, Erica Sarchielli, Marco Moretti,