Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3056873 | Experimental Neurology | 2007 | 10 Pages |
Abstract
We have analysed the expression of the endogenous angiogenesis inhibitor endostatin/collagen XVIII following stab wound injury and observed a highly significant (p < 0.0001) lesional accumulation confined to areas of pan-necrotic injury and developing secondary damage. Maximal cell numbers were detected at Day 14, declining until Day 21 after injury. Further, endostatin/collagen XVIII+ monocytic cells accumulated in Virchow-Robin spaces where they formed cell clusters. Besides being prevailingly localised to ED1+ activated microglia/macrophages, endostatin/collagen XVIII expression was also detected by subendothelial surrounding vessels in the lesioned area. Late and prolonged accumulation of endostatin/collagen XVIII+ microglia/macrophages and increased numbers of endostatin/collagen XVIII+ subendothelial cells/vessels in areas of vascular pruning and regression, point to a role in the termination of the transient angiogenic response, linked to a “late” inflammatory milieu.
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Authors
C.A. Mueller, H.J. Schluesener, U. Fauser, S. Conrad, J.M. Schwab,