Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3057105 | Experimental Neurology | 2007 | 6 Pages |
Abstract
Peri-infarct increase of vascular density has been observed in animals and in humans with ischemic stroke. Increased peri-infarct vascular density correlates with improved functional outcome after stroke. We hypothesized that pre-treatment with estradiol will increase post-ischemic peri-infarct capillary density in a rat model of transient ischemic stroke. Estradiol, compared to placebo, augmented post-ischemic peri-infarct vascular density by 22% 10Â days after stroke. Recovery of forelimb function was not improved with estradiol treatment on day three and nine post-stroke. Loss of estradiol may limit repair in the peri-infarct region by limiting angiogenesis, but functional significance in stroke recovery requires further investigation.
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Authors
Agnieszka A. Ardelt, Naseem Anjum, Kiran F. Rajneesh, Piotr Kulesza, Raymond C. Koehler,