| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3057374 | Experimental Neurology | 2006 | 4 Pages |
Abstract
Multipotential bone marrow stromal cells (MSCs) from wild-type (Wt) or apolipoprotein E deficient (Apoeâ/â) mice were implanted into the cerebral ventricles of Apoeâ/â mice. MSCs from Wt mice continued expressing apoE up to 6Â months after implantation and were associated with enhanced novel object recognition and increased microtubule-associated protein 2 (MAP2) immunoreactivity in the dentate gyrus. These data show that MSCs can be used to distinguish developmental from post-developmental effects of a gene knockout and support their therapeutic potential for neurodegenerative diseases.
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Authors
Alexandra Peister, Suzanne Zeitouni, Timothy Pfankuch, Roxanne L. Reger, Darwin J. Prockop, Jacob Raber,