Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3057410 | Experimental Neurology | 2006 | 5 Pages |
Abstract
Glutamate antagonists have recently been shown to limit tumor growth, providing potential new therapeutic targets and strategies against brain tumors. Here, we demonstrate that the glutamate NMDA receptor antagonist MK801, after a delay, adversely reverses functional recovery in rats with compressive mass lesions of the sensorimotor cortex. Our data suggest that the controlled focal cortical compression model may be a valuable pre-clinical tool to screen compounds for the treatment of brain tumors. It may be possible to use this model to develop interventions that maintain anti-cancer effects but with diminished harm to bystander tissue and brain plasticity.
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Neuroscience
Neurology
Authors
Hongyan Yang, Michael Chopp, Feng Jiang, Xuepeng Zhang, Timothy Schallert,