Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3061248 | Journal of Clinical Neuroscience | 2011 | 5 Pages |
Abstract
Tumor-induced secondary hyperprolactinemia in patients with non-prolactin (PRL)-secreting pituitary tumors has traditionally been ascribed to pituitary stalk damage. We conducted a retrospective analysis of secondary hyperprolactinemia in 106 patients who underwent surgery for non-PRL-secreting pituitary adenoma. The incidence of hyperprolactinemia was evaluated, and pituitary-stalk damage was assessed radiographically using MRI (size of tumor and extension type) and endocrinologically by monitoring hormonal function using a provocation test. The effect of a tumor-derived intrasellar factor, leukemia inhibitory factor (LIF), on hyperprolactinemia was also investigated. Hyperprolactinemia was observed in 31 of the 106 (29.2%) patients. It was not correlated with either physical stalk compression or endocrinological dysfunction. However, LIF expression was negatively correlated with the incidence of secondary hyperprolactinemia (p < 0.01). Although secondary hyperprolactinemia might be caused by pituitary stalk damage, it is possible that LIF masks the effect.
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Authors
Yasuyuki Kinoshita, Seiji Hama, Atsushi Tominaga, Kazunori Arita, Kazuhiko Sugiyama, Tetsuhiko Sakoguchi, Satoshi Usui, Kaoru Kurisu,