Integrin-linked kinase: A potential therapeutic target for the treatment of glioma

The diffuse infiltrative nature of cerebral glioma is a primary reason for failure of current treatment regimes. An improved understanding of the molecular determinants of tumour invasion is imperative in order to achieve therapeutic advances. Integrin-linked kinase has been shown to be key in the regulation of cell migration, as well as proliferation and apoptosis. The involvement of integrin-linked kinase in glioma biology, and its potential as a possible therapeutic target, is discussed.