Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3063396 | Journal of Clinical Neuroscience | 2007 | 4 Pages |
Abstract
The concentrations of oxidized coenzyme Q-10 (CoQ-10) and reduced CoQ-10 in the cerebrospinal fluid (CSF) of patients with Parkinson's disease (PD) was examined in order to determine whether the balance in oxidized and reduced CoQ-10 is related to the pathogenesis of PD. The percentage of oxidized/total CoQ-10 (%CoQ-10) in the CSF was significantly higher in the untreated PD group (80.3 ± 17.9%) compared to the normal control group (68.2 ± 20.4%) (p < 0.05). The %CoQ-10 in the CSF of PD patients showed significant negative correlation with the duration of illness. These findings in living patients provide in vivo evidence for a possible role for %CoQ-10 in the pathogenesis in the early stages of PD development.
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Authors
Chiaki Isobe, Takahiko Murata, Chigumi Sato, Yasuo Terayama,