Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3063464 | Journal of Clinical Neuroscience | 2009 | 5 Pages |
Abstract
We investigated the neuroprotective effects of pre- and postconditioning on infarct volume in the transient middle cerebral artery occlusion (MCAo) model in rats. Thirty-two male rats were divided into occlusion, preconditioning, postconditioning and both pre- and postconditioning groups. MCAo (120Â minutes) was monitored with continuous cerebral tissue oxygen (O2) pressure (PtiO2). Pre-conditioning comprised 10 minutes of MCAo, 24 hours prior to the 120 minute MCAo. The postconditioning algorithm was 30Â seconds of reperfusion followed by 30Â seconds of MCAo. This cycle was repeated 3 times at the onset of reperfusion. Comparison of infarct volumes showed a significant difference between the conditioned groups and occlusion group. Although there was better protection in the preconditioning group compared with the other two conditioned groups, the results did not reach statistically significant levels. The results suggest that preconditioning, postconditioning and pre/post conditioning have protective effects on cerebral ischemia.
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Authors
M. Ozgur Taskapilioglu, Tulin Alkan, Bulent Goren, Kudret Tureyen, Soner Sahin, Ozlem Taskapilioglu, Ender Korfali,