Article ID Journal Published Year Pages File Type
3063796 Journal of Neuroimmunology 2016 5 Pages PDF
Abstract

•Low-dose IL-2 improved mRS of AE patients at the last follow-up compared with the scale at the initiation of the treatment.•Low-dose IL-2 showed an acceptable side-effect profile in treating AE.•Low-dose IL-2 is a feasible and relatively safe treatment for AE refractory to the first- and second-line immunotherapies.

Low-dose interleukin-2 (IL-2) restores the balance of regulatory and effector T cells. We aimed to determine the feasibility of low-dose IL-2 as a treatment for refractory autoimmune encephalitis (AE). Ten patients who had received low-dose IL-2 were retrospectively identified. We observed an improvement in the modified Rankin Scale scores of six patients at the last follow-up compared with the scores at the initiation of low-dose IL-2 (p = 0.014). One patient experienced treatment-related grade 3 neutropenia. Overall, low-dose IL-2 is a feasible and relatively safe treatment for AE patients who are refractory to the first- and second-line immunotherapies.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (81 K)Download as PowerPoint slide

Related Topics
Life Sciences Immunology and Microbiology Immunology
Authors
, , , , , , , , , , , ,