| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3069499 | Neurobiology of Disease | 2012 | 10 Pages |
Abstract
⺠EGb 761 and its components are neuroprotective in a mouse transient ischemia model. ⺠Putative mechanism of action is through the Nrf2/HO1-induced CRMP2 pathway. ⺠EGb 761 can protect neurons in vitro from oxidative as well as excitatory toxicity. ⺠EGb 761 induces neuritogenesis by upregulating CRMP2. ⺠EGb 761 protected the filaments and restored filamental CRMP2 expression.
Keywords
MCAHO1ginkgolide ACRMP2Ginkgolide BEGb 761TMCAON-methyl-d-aspartateNDSTFMTTCNMDAt-BuOOHHydrogen peroxidemiddle cerebral artery occlusiontransient middle cerebral artery occlusionBilobalideTriphenyltetrazolium chlorideNeurite growthtertiary butylhydroperoxidemiddle cerebral arteryNeuroprotectionneurologic deficit scoreheme oxygenase 1H2O2collapsin response mediator protein 2Ginkgo biloba
Related Topics
Life Sciences
Neuroscience
Neurology
Authors
Shadia E. Nada, Zahoor A. Shah,