| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3069541 | Neurobiology of Disease | 2011 | 8 Pages |
Abstract
⺠Parkinson's disease (PD) may be due to a failure of survival signaling by PI3K/Akt. ⺠To test this we transduced dopamine neurons with dominant negative Akt, DN(PH)-Akt. ⺠In aged mice DN(PH)-Akt leads to a loss of dopaminergic phenotype in axons. ⺠This effect is additive in aged α-synuclein transgenic mice. ⺠We conclude that dopaminergic axonal phenotype is dependent on Akt signaling. ⺠This dependence is revealed in the presence of two principal risk factors for PD.
Keywords
Related Topics
Life Sciences
Neuroscience
Neurology
Authors
Sang Ryong Kim, Vincent Ries, Hsiao-Chun Cheng, Tatyana Kareva, Tinmarla F. Oo, W. Haung Yu, Karen Duff, Nikolai Kholodilov, Robert E. Burke,