Lack of evidence for a pathogenic role of T-lymphocytes in an animal model for Charcot-Marie-Tooth disease 1A

Article ID	Journal	Published Year	Pages	File Type
3069959	Neurobiology of Disease	2010	7 Pages	PDF

Abstract

These findings strongly suggest that lymphocytes are not pathogenetically relevant in this model for CMT1A. We suggest that - in contrast to myelin phagocytosing macrophages - T-lymphocytes are not a promising target for treatment of CMT1A.

Keywords

PD-1 CMT T-lymphocytes RAG-1 demyelination Peripheral Nerves Schwann cells Macrophages

Related Topics

Life Sciences Neuroscience Neurology

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Lack of evidence for a pathogenic role of T-lymphocytes in an animal model for Charcot-Marie-Tooth disease 1A

Authors

Bianca Kohl, Janos Groh, Carsten Wessig, Heinz Wiendl, Antje Kroner, Rudolf Martini,