Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3070625 | Neurobiology of Disease | 2006 | 5 Pages |
Abstract
A key event in the pathogenesis of Alzheimer's disease is the conversion of soluble amyloid Aβ-peptide into toxic aggregates. Here, we studied the effect of cholesterol depletion on the formation of insoluble Aβ. We found that reduction of neuronal cholesterol by ∼25% reduced the neuronal formation of insoluble Aβ without affecting the secretion of soluble Aβ. Moreover, we demonstrate that Aβ-oligomers from Alzheimer's disease brains associate with a detergent-resistant membrane fraction in a cholesterol-dependent manner. These results suggest a key role for cholesterol in aggregation of Aβ.
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Authors
Anja Schneider, Walter Schulz-Schaeffer, Tobias Hartmann, Jörg B. Schulz, Mikael Simons,