Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3076433 | Neurología | 2011 | 7 Pages |
Abstract
In our series, family history of ADEOD was a sensitive criterion for the detection of pathogenic mutations in AD and FTLD but not in prion diseases. No genetic anomalies were detected in 15% of the ADEOD cases using conventional diagnostic procedures, and 43% of pre-symptomatic subjects at risk who received individual genetic counselling decided to have the study. The pre-symptomatic diagnosis proved to be safe under these conditions.
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Authors
J. Fortea, A. Lladó, J. Clarimón, A. Lleó, R. Oliva, J. Peri, L. Pintor, J. Yagüe, R. Blesa, J.L. Molinuevo, R. Sánchez-Valle,