Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3078809 | Neurologic Clinics | 2007 | 14 Pages |
Abstract
Alzheimer's disease (AD) is a devastating neurodegenerative disease. To rationally develop novel therapeutic and/or preventative agents for AD, an understanding of the etiology and pathogenesis of this complex disease is necessary. This article examines the evidence for the amyloid hypothesis of AD pathogenesis and discusses how it relates to the neurological and neuropathological features of AD, the known genetic risk factors and causative mutations, and the heightened risk associated with advanced age.
Related Topics
Health Sciences
Medicine and Dentistry
Clinical Neurology
Authors
Christopher B. Eckman, Elizabeth A. Eckman,