| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3084282 | Pediatric Neurology | 2016 | 7 Pages |
Abstract
The respiratory difficulties our patient experienced during non-rapid eye movement (REM) sleep are characteristic of post-sigh central apnea. Exaggerated activity of expiratory neurons during such apneic events has been observed in mouse models of Rett syndrome. We suggest that prescribed serotonergic agents might serve to inhibit such activity, attenuating the imbalance between inspiratory and expiratory neurons. These agents might also be useful in the treatment of autistic-like behaviors caused by impaired serotonergic transmission in the brain.
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Authors
Koyo MD, Yoshiaki MD, PhD, Riyo MD, Masami MD, Takanori MD, Eriko MT, Misato MT, Yoshihiro MD, PhD,