| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3086234 | Pediatric Neurology | 2009 | 4 Pages |
Abstract
The case of a 4-year-old girl with valproate-induced stupor and electroencephalographic pattern of increased fast activity is reported. Stupor and fast activity have been related to the effects on γ-aminobutyric acid type A (GABAA) receptors mediated by endozepines or by exogenous drugs such as benzodiazepines or barbiturates. The action of valproate in GABA metabolism and in GABA neuronal networks could produce a similar result through a hyperrecruitment of GABA-mediated postsynaptic transmission.
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Authors
Mario MD, Rosanna MD, Alberto MD, PhD, Valerio Rocchi, Paola MD,