Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3087169 | Pratique Neurologique - FMC | 2015 | 7 Pages |
Abstract
Parkinsonism has been found in numerous hereditary metabolic or rare diseases. Familial history, young age of onset, associated neurological signs (spasticity, dystonia, ophtalmoplegia, ataxia, cognitive declineâ¦), neuroradiological abnormalities (metallic deposits, calcifications, cerebellar atrophyâ¦), dopa-resistance or early dopa-intolerance, can lead to the diagnosis. The main objectives are to detect treatable diseases (Wilson disease, cerebrotendinous xanthomatosis, Niemann-Pick disease, Gaucher disease, hypermanganesemiaâ¦), so genetic and prognostic advice can be proposed.
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Authors
C. Tranchant,