L'imagerie cérébrale des plaques amyloïdes : le point de vue du clinicien

The main pathology of Alzheimer's disease is characterized by two types of protein aggregates: extracellular plaques (containing Aβ aggregates) and neurofibrillary tangles (composed of tau protein aggregates). Biomarkers are becoming increasingly useful in the diagnostic approach of Alzheimer's disease. Diagnosis can be established earlier with amyloid neuroimaging to highlight in vivo cortical amyloid deposits. Amyloid imaging can be considered a “pathophysiological” biomarker independent of the clinical evaluation. Nevertheless, it remains difficult to differentiate Alzheimer's disease from other neurodegenerative diseases.