| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3091244 | Seminars in Pediatric Neurology | 2006 | 6 Pages |
Abstract
Neurofibromatosis types 1 and 2 (NF1 and NF2) are autosomal dominant phakomatoses. The NF1 and NF2 genes encode for neurofibromin and merlin, respectively. These 2 functionally unrelated proteins both act as tumor suppressor genes, possibly through modulation of the RAS/RAC oncogenic pathways. Improved understanding of the mechanisms by which these tumor suppressors act may allow for medical therapies for neurofibromatosis and may offer insights for cancer therapeutics.
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Authors
Kaleb H. Yohay,