| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3092334 | Surgical Neurology | 2009 | 7 Pages |
Abstract
The results of this study showed that MIB-1 LI is a rapid and cost-effective modality for predicting tumor grade in oligodendrogliomas. Immunohistochemistry for PDGF was found to be useful in differentiating various grades of oligodendroglioma, and therefore, it may be involved in tumor cell proliferation and malignant transformation. Platelet-derived growth factor receptor α, although expressed in oligodendroglial neoplasms, was not found to be useful in predicting tumor grade.
Keywords
NGFinsulinlike growth factor 1PCNAPDGFRαMIB-1SSVOligodendrogliomaPDGFPDGFRβABCIGF-1TGFβbFGFEGFDAB3,3-diaminobenzidine tetrahydrochlorideH&EProliferating Cell Nuclear AntigenImmunohistochemistryTransforming growth factor βWorld Health Organizationlabeling indexepidermal growth factorVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)platelet-derived growth factornerve growth factorbasic fibroblast growth factorProliferative activityAvidin-biotin complexHematoxylin and Eosinpolymerase chain reactionPCRplatelet-derived growth factor receptor βWHOReceptorplatelet-derived growth factor receptor α
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Authors
Kaushik MD, DNB, Bishan D. MD, PhD, Rakesh K. MD, FRCPath, Ashish MS, MCh,