Neural tube defects at separate sites: further evidence in support of multi-site closure of the neural tube in humans

BackgroundThe presence of MMC at multiple sites or their association with encephalocele is a very rare event. Only few cases of multiple NTDs have been described in world literature in the form of isolated case reports.Case DescriptionWe report 4 cases of multiple NTDs. We also review the theories of etiopathogenesis of multiple NTDs.ConclusionThe multiple-site closure of NT theory is most useful in describing the occurrence of multiple NTDs in our cases.