Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3094130 | Surgical Neurology | 2006 | 6 Pages |
Abstract
Antisense oligonucleotide targeting c-Met can be identified as a most potent AS compound, which can inhibit cell growth and induce cell apoptosis. This provides evidence that c-Met plays a role in tumor progression of glioma by acting as an oncogene and suggests that c-Met ASODN may provide a novel approach to therapy for human glioma.
Keywords
TGF-βFCMEGFTgf-αPBSHGFFAMRT-PCRc-MetDMSOMTTODNsantisense oligonucleotideAntisensetransforming growth factor-αtransforming growth factor-βApoptosisDimethyl sulfoxidefigureFig.epidermal growth factorHepatocyte growth factorFlow cytometryPhosphate-buffered salineNonsenseGene therapyGliomahepatocyte growth factor receptor
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Authors
Shenghua Chu, Xianhou Yuan, Zhiqiang Li, Pucha Jiang, Jie Zhang,