| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3097902 | Chinese Herbal Medicines | 2015 | 4 Pages |
Abstract
ObjectiveTo study the water-soluble chemical constituents from the rhizomes of Atratylodes lancea.MethodsTwo sesquiterpenoid glycosides were purified by column chromatography and their structures were determined by spectroscopic analysis. They were also evaluated for anti-inflammatory activity by determining the inhibitory activity on LPS-induced NO and PGE2 generation in RAW 264.7 cell lines.ResultsCompound 1 was a new sesquiterpenoid glycoside, named as (1S,4S,5R,7R,10S)-4,11,14-trihydroxy-guai-3-one-11-O-β-D-glucopyranoside, but exhibited no appreciable activity. Compound 2 was atractyloside A and showed weak activity.ConclusionThe hydroxyl group at C-10 of guaiol-type glycoside could be important for anti-inflammatory activity.
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