HIV prevention and treatment strategies can help address the overdose crisis

•Opioid overdoses are a major public health issue.•HIV strategies reduce deaths and infections among people who use drugs.•Successful HIV approaches should be applied to the opioid overdose crisis.

Since the 1990s, effective HIV prevention and treatment strategies have been coordinated and implemented in the United States, resulting in substantial reductions in HIV-related death and HIV transmission among people who use injection drugs. During the same period, despite substantial long-term funding of War on Drugs policies, opioid addiction, driven by increased prescription opioid use and heroin accessibility, has made overdose the leading cause of accidental injury death in the United States. This commentary describes how the prevention and treatment successes among people who use drugs in the HIV/AIDS epidemic can be applied to address the opioid overdose crisis.