Clinical efficacy of Chifeng Yingyuan manipulation for migraine and its effects on endothelin and nitric oxide

ObjectiveTo observe clinical efficacy of Chifeng Yingyuan manipulation for migraine and its effects on endothelin (ET) and nitric oxide (NO).MethodsOne hundred and seventeen cases were randomly divided into a treatment group (59 cases) and a control group (58 cases). The Chifeng Yingyuan manipulation was applied in the treatment group while oral administration of flunarizine hydrochloride capsules was applied in the control group for consecutive 4 weeks. Before and after the treatment, the clinical efficacy and migraine score in both groups were compared; radioimmunoassay was used to test level of ET while nitrate reductase method was for level of NO.ResultsCompared between two groups, the total effective rate was 91.5% in the treatment group, which was superior to 70.7% in the control group (P<0.05). After the treatment, the migraine scores were both significantly decreased in two groups (P<0.05, P<0.01), which was more obvious in the treatment group (P<0.05). The level of ET and NO was significantly changed after treatment (P<0.05, P<0.01). Compared between two groups, the improvement of ET and NO in the treatment group was better than that in the control group (both P<0.05).ConclusionThe Chifeng Yingyuan manipulation has positive effect on migraine without any adverse reaction, which could maintain cerebrovascular vasomotor function by regulating level of ET and NO in the plasma.