Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3105223 | Burns | 2009 | 5 Pages |
Abstract
Burn combined with inhalation injury is a major challenge and requires further study. Using a small-animal model, excretion of IL-6 was investigated during the first 6 h after exposure of rats to wood/polyvinyl chloride smoke, with and without concomitant skin burn. In controls, respirator therapy alone was found to release IL-6 into the serum and the alveolar space. These levels of IL-6 were reduced when associated with either inhalation injury or burn, but were increased when the traumas were combined. Thus, during the first 6 h of mechanical respiration the presence of burn or of inhalation injury seems to decrease IL-6 excretion, but a combination of these traumas reverses this effect.
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Authors
P.C. Fuchs, E. Demir, K. Reuber, P. Stromps, T. Wolter, N. Pallua,