Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3105724 | Burns | 2008 | 5 Pages |
Abstract
Oxidants are involved in the pathogenesis of many disorders caused by burn and smoke inhalation; α- and γ-tocopherols are major tissue antioxidants, and their depletion should reflect oxidant injury. To determine whether plasma and tissue vitamin E levels would thus be depleted in severe burn, prepared sheep were randomly divided into the following groups: non-injured, burn- and smoke-exposed, burned only and smoke-exposed only. All were resuscitated with Ringer's lactate solution, mechanically ventilated and sacrificed at various time intervals. Immediately following injury plasma, lung, trachea, heart and liver tocopherols/lipids were measured and found to be significantly depleted except in the heart. Reduction of tissue γ-tocopherol appeared earlier than reduction of α-tocopherol. Thus animals receiving combined burn and inhalation injury underwent marked oxidative stress, suggesting that vitamin E might be depleted also in humans with burn and smoke inhalation injury, and that appropriate supplementation should be evaluated.
Keywords
Related Topics
Health Sciences
Medicine and Dentistry
Critical Care and Intensive Care Medicine
Authors
Katsumi Shimoda, Hiroaki Nakazawa, Maret G. Traber, Daniel L. Traber, Motohiro Nozaki,