Article ID Journal Published Year Pages File Type
3106263 Burns 2010 7 Pages PDF
Abstract
The pharmacokinetic characteristics of a propofol bolus administered in patients with major burns were enhanced clearance and expanded volume of distribution. BURN and WT were the important covariates. For sedation or anesthesia induction, a higher than recommended dose of propofol may be required to maintain therapeutic plasma drug concentrations in patients with severe burns. Vigilance regarding the burned individual and careful titration of hypnotics to the desired effect cannot be overemphasized.
Related Topics
Health Sciences Medicine and Dentistry Critical Care and Intensive Care Medicine
Authors
, , ,