Effect of Xuebijing injection on peripheral T-lymphocyte subpopulations in patients with severe trauma

ObjectiveTo investigate the effect and clinical significance of Xuebijing injection on peripheral T-lymphocyte subpopulations in patients with severe trauma.MethodsThirty-three patients with severe trauma were randomly divided into a control group (n=16) and a treatment group (n=17). The patients of two groups were all treated conventionally, and the only difference was that Xuebijing injection was given to patients of the treatment group. The CD+4 and CD+8 subpopulations of T-lymphocyte in the perioheral blood were detected respectively on admission, 3rd and 5th days after trauma by double antibody labeling and flow cytometry.ResultsThe CD+4 T-lymphocytes and CD+4/CD+8 ratio of peripheral blood in patients with severe trauma decreased markedly on the 3rd and 5th days after trauma. Further more, compared with control group, the peripheral CD+4 T-lymphocytes and CD+4/CD+8 ratio of treatment group renewed obviously on the 5th day after trauma, and showed statistical differences (P<0.05).ConclusionIn the treatment of patients with severe trauma, the early use of Xuebijing injection is effective in correcting disorder or suppression of T-lymphocyte subpopulations regulating network, and promoting a more balanced profile of immunologic function.