Article ID Journal Published Year Pages File Type
3107941 Clinical Queries: Nephrology 2014 6 Pages PDF
Abstract

Antiphospholipid antibody syndrome (APS) is characterized by recurrent pregnancy losses and/or thrombotic events (both arterial and venous) with persistently positive lupus anticoagulant or antiphospholipid antibodies. Activation of complements, platelets and endothelial cells by the anticardiolipin-β2GP-1 complex plays a major role in pathogenesis of thrombosis. Treatment is with anticoagulation (warfarin/heparin), with steroids needed in the presence of catastrophic APS or cytopenias. Upto a third of patients may have significant long term morbidity.

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