| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3120737 | Archives of Oral Biology | 2016 | 8 Pages |
•E-cad, B-Cat and Ki-67 were investigated in oral SCC and BSCC.•There is no difference of expression of B-cat and E-cad in oral SCC and BSCC.•Lower expression of E-Cad and B-cat in cytoplasmic membrane and high in cytoplasm.•Ki-67 expression has no significance in the ITF of SCC and BSCC in oral cavity.•There is no significant difference between these lesions in oral cavity.
ObjectiveInvestigate, on a comparative basis, the expression of the adhesion molecules E-cadherin (E-cad), β-catenin (β-cat) and the proliferation index (Ki-67) at the invasive tumor front (ITF) in squamous cell carcinoma (SCC) and basaloid squamous cell carcinoma (BSCC).Material and methodsThirty-five SCC and 16 BSCC cases were evaluated by immunohistochemistry. Clinicopathological and survival data were also evaluated and compared.ResultsThere was a low expression of E-cad in the cytoplasmic membrane (p = 0.50) as well as in the nucleus (p = 0.31) for both SCC and BSCC. A high expression of E-cad was seen in the cytoplasm for the SCC group (80%) when compared to the BSCC group (25%) (p < 0.01). The expression of β-cat was low in the cytoplasmic membrane and high in the cytoplasm in both SCC and BSCC groups. Both types of carcinoma presented low expressions of β-cat in the nucleus (p = 0.03). The Ki-67 expression was low irrespective of tumor variant. The high expression of E-cad in the cytoplasm was associated with T3/T4 tumors (p = 0.04) in the SCC group and there was no significant association of E-cad, β-cat, Ki-67 with the other clinical variables. In terms of disease-free survival and overall survival, there were no significant differences between SCC and BSCC.ConclusionThe E-cad–β-cat system was found to be dysregulated in both oral SCC and oral BSCC. The Ki-67 cell proliferation index was extremely low in the cases investigated and consequently had no prognostic value.
