Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3135167 | International Journal of Oral and Maxillofacial Surgery | 2006 | 4 Pages |
Abstract
P16 promoter methylation occurs frequently in oral squamous cell carcinoma (OSCC). For the early detection of tumour-related aberrant DNA, we examined p16 methylation using the methylation-specific polymerase chain reaction (MSP) in tumour and serum samples of 17 OSCC patients. Aberrant p16 methylation was detected in 11 (64.7%) cases of primary OSCC. Of these 11 patients, 6 (54.5%) showed the same alteration in their serum. No methylation was found in control groups. Interestingly, DNA was detected in the serum of 3 out of 4 patients with recurrence. These results suggest that the MSP may be a sensitive and useful method for detecting recurrent OSCC.
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Authors
Y. Nakahara, S. Shintani, M. Mihara, S. Hino, H. Hamakawa,