Bifosfonati: note storiche, terapie e protocolli

Millions of patients are receiving bisphosphonates for the treatment of osteoporosis, and ONJ is one of the most common complications observed in such patients. The typical patient with ONJ is a female, >50 years of age, with a history of dental surgery or trauma. Dentists play a primary role in the treatment of ONJ associated with the use of bisphosphonates. However, definitive conclusions on the causal relation between oral bisphosphonate use and ONJ are not possible at this time because these drugs are still being investigated and the results emerging from different studies are sometimes discordant.