Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3137026 | Japanese Dental Science Review | 2009 | 5 Pages |
Abstract
SummaryAutoimmune diseases reveal complex and multigenic phenotypes affected by a variety of genetic and environmental or stochastic factors. A lot of models for autoimmune diseases including Sjögren's syndrome (SS) have been demonstrated using gene-manipulated or other animals. Previous findings obtained with both animal models and patients with SS indicate involvement of a T cell with a T helper type 1 (TH1) phenotype. This review focuses on the T cell-dependent autoimmune disease such as SS to understand the molecular mechanism of regulation of T cell activation in autoimmunity, and highlights the pathogenesis of autoimmune disease.
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Authors
Naozumi Ishimaru, Yoshio Hayashi,