Preoperative radiochemotherapy in the treatment of advanced oral cancer: Outcome of 276 patients

SummaryIntroductionThe aim of this study was to review survival and locoregional control in patients with advanced oral and oropharyngeal squamous cell carcinoma treated by multimodal therapy with preoperative radiochemotherapy and radical surgery.MaterialRetrospective cohort study.MethodsIncluded in this analysis are 276 consecutive patients with UICC disease stages III and IV (T2: 13.0%; T3: 16.7%; T4: 70.3%; N0: 29.7%; N1: 20.3%; N2: 45.3%; N3: 4.7%; stage III: 16.3%; stage IV: 83.7%). All patients received preoperative radiochemotherapy (50 Gy, Mitomycin and 5-Fluorouracil) and radical locoregional resection.ResultsMedian surveillance period was 101.4 months (24–202 months). 5-year overall survival probability was 53.9%. 5-year local control probability was 70.2%.ConclusionThese results underline the reliability of preoperative treatment of patients with oral and oropharyngeal cancer.