| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3147298 | Journal of Endodontics | 2012 | 7 Pages |
Abstract
We found a negative relation between autophagy and apoptosis in osteoblastic cells. In addition, simvastatin suppressed apoptosis and enhanced autophagy both in vitro and in vivo. Our data implied that simvastain might alleviate the progression of apical periodontitis by promoting autophagy to protect osteoblasts from turning apoptotic.
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Authors
Eddie Hsiang-Hua DDS, MS, Chi-Yuan DDS, DMSc, Sang-Heng DDS, PhD, Kuo-Liang MS, Ling-Hsiu DDS, Li-Deh DDS, PhD, Mu-Hsiung BS, Ping-Han DDS, MS, Sze-Kwan DDS, PhD,