Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3152168 | Journal of Oral and Maxillofacial Surgery | 2016 | 10 Pages |
Abstract
Unlike a 2-N loading force, mechanical overloading of the TMJ using a 3.5-N loading force induced constant and nonresolving pain and the upregulation of inflammatory markers only in the 3.5-N group, suggesting that these markers could predict the maintenance of persistent orofacial pain. As such, the development of a tunable experimental TMJ-OA model that can separately induce acute or persistent orofacial pain using similar approaches provides a platform to better understand the pathomechanisms involved and possibly to evaluate potential treatment strategies for patients with painful TMJ-OA.
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Authors
Sonia BS, Timothy Zhou, Eric J. DMD, MD, Beth A. PhD,