| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3164055 | Oral Oncology | 2014 | 9 Pages |
Abstract
SummaryObjectiveTo develop in vitro adenoid cystic carcinoma cell line as a surrogate for functional studies.Materials and methodsCells obtained from a primary ACC of the base of tongue were cultivated in vitro and immortalized with h-TERT. Morphologic, cytogenetic and functional studies were performed.ResultsTumor cells were verified by positive reactions to keratin and smooth muscle actin and phenotypic cellular and nuclear features. In-vitro cell growth and colony formation assay supported their tumor nature.ConclusionWe authenticated an ACC cell line with hybrid epithelial–myoepithelial feature as a resource for functional experimentation.
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Authors
Jie Li, Laszlo Perlaky, Pulivarthi Rao, Randal S. Weber, Adel K. El-Naggar,