Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3165148 | Oral Oncology | 2010 | 5 Pages |
Abstract
A significant long-term side effect of radiation therapy for head and neck cancers is xerostomia, a dry mouth, due to salivary gland damage. Despite continuing efforts to eliminate this problem, many patients continue to suffer. This brief review describes our efforts to develop a gene transfer approach, employing the aquaporin-1 cDNA, to treat patients with existing radiation-induced salivary hypofunction. A Phase I/II clinical trial, using a recombinant adenoviral vector to mediate gene transfer, is currently underway.
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Authors
Bruce J. Baum, Changyu Zheng, Ilias Alevizos, Ana P. Cotrim, Shuying Liu, Linda McCullagh, Corinne M. Goldsmith, Nancy McDermott, John A. Chiorini, Nikolay P. Nikolov, Gabor G. Illei,