Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3165215 | Oral Oncology | 2010 | 4 Pages |
Abstract
We analyzed the expression of Id-1 in oral squamous cell carcinoma (OSCC) immunohistochemically, and investigated the association of Id-1 expression with tumor angiogenesis and clinical prognosis. Overexpression of Id-1 protein was found in 83 out of 128 cases (64.8%). The expression of Id-1 was significantly associated with tumor size (p = 0.013), lymph node metastasis (p = 0.001), tumor stage (p = 0.031) and tumor recurrence (p = 0.003). Moreover, Id-1 expression was significantly correlated with intratumoral microvessel density (MVD) (r = 0.223, p = 0.011). The results suggest that overexpression of Id-1 was correlated with tumor angiogenesis and poor clinical outcome.
Related Topics
Health Sciences
Medicine and Dentistry
Dentistry, Oral Surgery and Medicine
Authors
Zuoqing Dong, Shaohua Liu, Chengjun Zhou, Tomoki sumida, Hiroyuki Hamakawa, Zhenggang Chen, Pei Liu, Fengcai Wei,