Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3165719 | Oral Oncology | 2007 | 8 Pages |
SummaryThis study tested the hypothesis that GLUT-1 is a marker of radioresistance in oral squamous cell carcinomas (OSCC). A GLUT-1 labeling index (LI) was determined by immunohistochemistry in 40 pretreatment OSCC biopsies. Radiation responses were categorized by histopathology of the resection specimens. Associations between the LI and radiation response, Kaplan-Meier survival estimates and Cox regression analysis for the variables GLUT-1, T-stage, N-stage and chemotherapy were examined. The median LI was 64.2% (range 14–100%). Tumors with >65% of GLUT-1 + cells were more resistant to radiation (p = 0.023). Overall survival was higher (p = 0.044) for subjects with low LI (