Accuracy of magnetic resonance imaging–cone beam computed tomography rigid registration of the head: an in-vitro study

ObjectiveTo evaluate the performance of cross-modality image registration procedure between magnetic resonance imaging (MRI) and cone beam computed tomography (CBCT).MethodsIn vitro diagnostic MRI and CBCT images of 5 cadaver swine heads were obtained prospectively. Five radiopaque fiducial markers were attached to each cadaver skull by using resin screws. Automatic MRI-CBCT rigid registrations were performed. The specimens were then scanned using a 3-dimensional (3-D) laser scanner. The 3-D coordinate points for the centroid of the attached fiducial markers from laser scan were identified and considered ground truth. The distances between marker centroids were measured with MRI, CBCT, and MRI-CBCT. Accuracy was calculated by using repeated measures analysis of variance and mean difference values. The registration method was repeated 10 times for each specimen in MRI to measure the average error.ResultsThere was no significant difference (P > .05) in mean distances of the markers between all images and the ground truth. The distances' mean difference between MRI, CBCT, and MRI-CBCT and the ground truth were 0.2 ± 1.1 mm, 0.3 ± 1.0 mm, 0.2 ± 1.2 mm, respectively. The detected method error ranged between 0.06 mm and 0.1 mm.ConclusionThe cross-modality image registration algorithm is accurate for head MRI-CBCT registration.