Article ID Journal Published Year Pages File Type
3167544 Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 2010 9 Pages PDF
Abstract

ObjectiveWe investigated whether administration of mesenchymal stem cells (MSCs) promotes bone formation at the gap created by periosteal distraction.Study designA mesh plate was placed subperiosteally in rabbit parietal bones. Following elevation of the mesh plate, rabbit MSCs were administered into the gap. Controls received phosphate-buffered saline (PBS). The volume, height, bone mineral density (BMD), and bone mineral content (BMC) of newly formed bone were examined using microcomputed tomography. Histological analysis was performed by hematoxylin and eosin staining and immunohistochemistry for type I collagen and osteocalcin.ResultsThe experimental group showed significantly increased volume, height, BMD, and BMC in newly formed bone tissues at the gaps compared with the control group (P < .05). The newly formed bone tissues showed both type I collagen and osteocalcin expression in the MSC-administration group.ConclusionMesenchymal stem cell administration may be useful to induce osteogenesis at sites of periosteal distraction.

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Health Sciences Medicine and Dentistry Dentistry, Oral Surgery and Medicine
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