| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3167741 | Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology | 2010 | 7 Pages |
Abstract
In this study, we detected the expression of phosphylated ERK1/2 in human salivary adenoid cystic carcinoma (SACC) by immunohistochemical method, the effect of various concentrations of PD98059 on the growth of ACC-M cells (a cell line of human adenoid cystic carcinoma of the salivary glands) by MTT assay, and the effect of PD98059 on the lung metastasis of inoculated ACC-M cells in nude mice. The results showed that the phosphylated ERK1/2 was overexpressed in SACC, the ACC-M cell line proliferation was inhibited by PD98059, and the lung metastasis level was reduced by PD98059, indicating that ERK may be a key molecule in targeted therapy of adenoid cystic carcinoma.
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Authors
Ji-an Hu, Yining Li, Jinhua Fang,