| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3167774 | Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology | 2009 | 5 Pages |
ObjectiveThe aim of this experimental study was to evaluate the effects of osteoformin on mineralization and quality of newly formed bone during distraction osteogenesis in rabbits.Study designDistraction rate was as 1 mm/day for 5 days. In the experimental group, 100 μg/kg osteoformin in 100 μL/kg phosphate-buffered saline (PBS) was injected into the distraction area at day 1 and day 7 after surgery. In the control group, only 100 μL/kg PBS was injected on the same days. On day 42, the animals were killed.ResultsBone mineral density and bone mineral content values increased significantly in the experimental group (P < .05). Newly formed bone areas, number of vessels and osteoblasts were significantly greater in experimental group (P < .05). The number of fibroblasts were also greater, but it was not significant statistically (P > .05). The number of osteoclasts was significantly lower in experimental group (P < .05).ConclusionThe results of this study show that osteoformin improves healing of regenerate in distraction osteogenesis in rabbits.
